Lithium hydride → [2-(6-Methyl-5-nitro-pyridin-2-yloxy)-ethyl]-propyl-carbamic Acid Tert-Butyl Ester

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-2-methyl-3-nitro-pyridine (1 g, 5.79 mmol), (2-hydroxyethyl)-propyl-carbamic acid tert-butyl ester (1.18 g, 5.79 mmol) and lithium hydride (0.05 g, 6.37 mmol) in toluene (5 ml) was stirred at 90° C. for 4 h. After evaporation of the solvent under reduced pressure the residue was purified by silica gel chromatography with heptane/ethyl acetate (10:0; 8:2; 0:10) as eluent to provide 1.38 g (70.2%) of the product.

Provenance & Evidence