HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-(6-Methyl-5-nitro-pyridin-2-yloxy)-ethyl]-propyl-carbamic Acid Tert-Butyl Ester → [2-(5-Amino-6-methyl-pyridin-2-yloxy)-ethyl]-propyl-carbamic Acid Tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-(6-Methyl-5-nitro-pyridin-2-yloxy)-ethyl]-propyl-carbamic Acid Tert-Butyl Ester | HCID 66883393 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [2-(5-Amino-6-methyl-pyridin-2-yloxy)-ethyl]-propyl-carbamic Acid Tert-Butyl Ester | HCID 66881282 | 84.5% |
Reaction Steps
A solution of [2-(6-methyl-5-nitro-pyridin-2-yloxy)-ethyl]-propyl-carbamic acid tert-butyl ester (300 mg, 0.88 mmol) in methanol (10 ml) was hydrogenated using the ThalesNano H-Cube® hydrogenation reactor employing a 10% palladium on charcoal catalyst cartridge. After concentration of the solution under reduced pressure, 230 mg (84.2%) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383641B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-8b43234660954cb0884c5e7e2b3db1a1 |
| Source note | uspto-grants-2013_02 |