Chlorosulfonic acid → HCID 55280761, compound

HRID 390309Notes

Reaction equation

HRID 390309 reaction equation
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Cl:11][S:12](O)(=[O:14])=[O:13]>>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:12]([Cl:11])(=[O:14])=[O:13])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 136254Benzene, 2-fluoroethoxy-

Product 1

HCID 55280761HCID 55280761, compound

Conditions

Temperature
2.5 °C

Procedure

At 0° C., (2-fluoro-ethoxy)-benzene (20 mmol) was added slowly to chlorosulfonic acid (200 mmol). The reaction mixture was stirred for 20 min at 0-5° C. and then warmed to room temperature, and finally stirred at 45° C. for 2 h. Then the reaction mixture was cautiously (!) added to ice water. The precipitate was filtered, washed with water and dried in a vacuum oven at 30° C. to give the title compound.

Workup

  1. temperaturewarmed to room temperature
  2. stirringfinally stirred at 45° C. for 2 h
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. customdried in a vacuum oven at 30° C.

Sources & evidence

ORD record
ord-c68c7d35781040ea803d571974233c68
Source dataset
uspto-grants-2013_02
Patent number
US08383641B2

Reaction notes

Loading…