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HRID39031

反应详情

EQUATION

反应方程式

HRID 39031 的结构方程式

REACTANTS

反应物

3
结构：CO
HCID887

Methanol

CH4O

结构：OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O
HCID441036

未命名化合物

结构：CCOC(=O)c1cc(=O)c2ccc(S(C)(=O)=O)cc2o1
HCID66878357

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1CCc2ccc(S(C)(=O)=O)cc2O1
HCID66879141

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A mixture of ethyl 7-(methylsulfonyl)-4-oxo-4H-chromene-2-carboxylate (1.3 g, 4.4 mmol), palladium on carbon (10%, 0.44 g), MeOH (45 ml) and AcOH (5 ml) was hydrogenated at 40 Psi for 64 h at 60° C. Filtration through Celite (EtOAc) and evaporation followed by filtration through a plug of Al2O3 (EtOAc/ACN) gave the title compound. Yield: 0.6 g. MS m/z (rel. intensity, 70 eV) 307 (64), 302 (91), 286 (14), 285 (M+1, bp), 211 (18).

WORKUP

后处理

  1. filtrationFiltration
  2. customthrough Celite (EtOAc) and evaporation
  3. filtrationfollowed by filtration through a plug of Al2O3 (EtOAc/ACN)