HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-nitro-6-[(1-propionylpyrrolidin-3-yl)oxy]pyridine → 2-Methyl-6-[(1-propionylpyrrolidin-3-yl)oxy]pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-nitro-6-[(1-propionylpyrrolidin-3-yl)oxy]pyridine | HCID 66883252 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methyl-6-[(1-propionylpyrrolidin-3-yl)oxy]pyridin-3-amine | HCID 66883429 | — |
Reaction Steps
2-Methyl-3-nitro-6-[(1-propionylpyrrolidin-3-yl)oxy]pyridine (940 mg) was dissolved in methanol (50 mL) and hydrogenated (H-cube from ThalesNano, 10% Pd/C, 60° C., 50 bar, 1 mL/min). The methanol was removed in vacuo. Yield: 800 mg (95%, colorless oil).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383641B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-7466fc78fae243f4915324cb9415e22c |
| Source note | uspto-grants-2013_02 |