HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 39032Generated: October 29, 2026
Hydrochloric Acid → [7-(Methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methanol
https://huagongshe.com/reaction/39032
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | Ethyl 7-(methylsulfonyl)chromane-2-carboxylate | HCID 66879141 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | [7-(Methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methanol | HCID 66878595 | — |
Reaction Steps
A mixture of ethyl 7-(methylsulfonyl)chromane-2-carboxylate (0.6 g, 2.1 mmol), LiBH4 (0.18 g, 8.5 mmol) and THF (8 ml) was stirred at 0° C. for 15 min and 2 h at room temperature. HCl (10%) and EtOAc was added, the organic phase was dried (Na2SO4), filtered and concentrated to give the title compound. Yield 0.66 g. MS m/z (rel. intensity, 70 eV) 507 (20), 485 (25), 265 (23), 244 (13), 243 (M+1, bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08524766B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-3a584eaecbf348fa818d3175309be6d8 |
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| Source note | uspto-grants-2013_09 |
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