HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-amino-4-bromonaphthalene-2-carboxylate → 3-[(1S,2S)-2-Hydroxycyclohexyl]-4-oxo-3,4-dihydropyrido[3,4-h]quinazoline-6-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-amino-4-bromonaphthalene-2-carboxylate | HCID 58431835 | — |
| Reactant | 3-[(1S,2S)-2-hydroxycyclohexyl]-4-oxo-3,4-dihydrobenzo[h]quinazoline-6-carbaldehyde | HCID 86672485 | — |
| Product | 3-[(1S,2S)-2-Hydroxycyclohexyl]-4-oxo-3,4-dihydropyrido[3,4-h]quinazoline-6-carbaldehyde | HCID 86672484 | — |
Reaction Steps
3-[(1S,2S)-2-Hydroxycyclohexyl]-4-oxo-3,4-dihydropyrido[3,4-h]quinazoline-6-carbaldehyde was prepared by the procedure described for the synthesis of 3-[(1S,2S)-2-hydroxycyclohexyl]-4-oxo-3,4-dihydrobenzo[h]quinazoline-6-carbaldehyde in Example 2, substituting methyl 5-amino-8-bromoisoquinoline-6-carboxylate for methyl 1-amino-4-bromo-2-naphthoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383638B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-862684922f004564bff45336f35d7477 |
| Source note | uspto-grants-2013_02 |