huagongshe.com
HRID39034

反应详情

EQUATION

反应方程式

HRID 39034 的结构方程式

REACTANTS

反应物

2
结构：N
HCID222

Ammonia gas

H3N

结构：Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc(S(C)(=O)=O)cc3O2)cc1
HCID86652935

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)c1ccc2c(c1)O[C@@H](CN)CO2
HCID66878351

未命名化合物

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

A mixture of [(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (1.1 g, 2.5 mmol), NH3 (4 ml, 7N in methanol) was heated under microwave radiation at 120° C. for 20 min. The product was evaporated to dryness and was purified by flash column chromatography (EtOAc/MeOH). Yield 0.31 g. MS m/z (rel. intensity, 70 eV) 243 (M+, 35), 214 (bp), 199 (35), 79 (25), 56 (22).

WORKUP

后处理

  1. customThe product was evaporated to dryness
  2. customwas purified by flash column chromatography (EtOAc/MeOH)