HRID39035

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

结构：Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1

HCID86652937

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1cc(F)c2c(c1)O[C@@H](CN)CO2

HCID67198473

未命名化合物

CONDITIONS

反应条件

温度: 120 °C

PROCEDURE

实验过程

A mixture of [(2R)-5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.7 g, 1.7 mmol), NH3 (6 ml, 7N in methanol) was heated under microwave radiation at 120° C. for 20 min. The product was evaporated to dryness and was purified on an SCX-3 column (TEA/MeOH) Yield 0.34 g. MS m/z (rel. intensity, 70 eV) 261 (M+, bp), 217 (49), 97 (39), 69 (55), 56 (79).

WORKUP

后处理

customThe product was evaporated to dryness
customwas purified on an SCX-3 column (TEA/MeOH) Yield 0.34 g