HCID 58458939, compound → HCID 136163958, compound

Participants

Reaction Steps

A solution of 5-(benzyloxy)-2-cyclopentyl-6-(3-(4-fluorobenzyl)-1,2,4-oxadiazol-5-yl)-3-methylpyrimidin-4(3H)-one (0.248 g, 0.54 mmol) in TFA (5 mL) was stirred 4 h at room temperature. The resulting yellow reaction mixture was then concentrated and the residue was crystallized from EtOH/H2O to afford the title (0.184 g, 92% yield) as a yellow solid. 1HNMR (500 MHz, CDCl3) δ: 9.74 (1H, s), 7.30 (2H, dd, J=8.2, 5.5 Hz), 7.01 (2H, t, J=8.6 Hz), 4.15 (2H, s), 3.64 (3H, s), 3.21-3.15 (1H, m), 2.04-2.00 (4H, m), 1.89-1.82 (2H, m), 1.72-1.64 (2H, m). HRMS (M+H) calcd for C19H20N4O3F: 371.1520. found: 371.1535. Anal calcd for C19H19N4O3F: C, 61.61; H, 5.17; N, 15.12; F, 5.13. found: C, 61.92; H, 5.54; N, 14.87; F, 5.10.

Provenance & Evidence