反应详情

温度

60 °C

A mixture of quinolin-8-yl(1-trityl-1H-imidazol-5-yl)methanol, (Intermediate 12) 3.7 g, 7.9 mmol) in CH2Cl2 (50 mL) was treated with manganese(IV) oxide, activated (commercially available from Aldrich): MnO2 (4.1 g, 47.4 mmol) at room temperature. The mixture was heated to 60° C. for 2 h. The mixture was then cooled to room temperature and filtered through celite and the solvent was removed under vacuum to get quinolin-8-yl(1-trityl-1H-imidazol-5-yl)methanone, (Intermediate 13) (3.6 g, 97%).

1. customat room temperature
2. temperatureThe mixture was then cooled to room temperature
3. filtrationfiltered through celite
4. customthe solvent was removed under vacuum