Potassium Carbonate → HCID 50907827, compound

Participants

Reaction Conditions

Reaction Steps

Step 3 Ethyl 2-(5-(2-(4-(4-fluorophenyl)spiro[chromene-2,4′-piperidine]-1′-yl)thiazol-5-yl)-2H-tetrazol-2-yl)acetate In a pressure vial, a mixture of 4-(4-fluorophenyl)spiro[chromene-2,4′-piperidine] (128 mg, 0.433 mmol), Intermediate 4 (175 mg, 0.550 mmol) and K2CO3 (127 mg, 0.919 mmol) were suspended in dry DME (2 mL). The vial was sealed and the mixture was stirred under N2 at an external temperature of 110° C. for 2 h. The reaction mixture was then cooled to room temperature, and diluted with DCM/methanol and concentrated under reduced pressure in the presence of silica gel. The resulting solid residue was purified by Combiflash™ chromatography (SiO2 (12 g), eluting with 3-10% EtOAc/hexanes) to afford the title compound as a solid.

Provenance & Evidence