HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl 7-(methylthio)chromane-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 7-mercaptochromane-2-carboxylate | HCID 66878558 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 7-(methylthio)chromane-2-carboxylate | HCID 66878197 | 90.9% |
Reaction Steps
A mixture of ethyl 7-mercaptochromane-2-carboxylate (3.4 g, 14.3 mmol), Methyliodide (3.03 g, 21.4 mmol) and K2CO3 (7.88 g, 57 mmol) in ACN (100 ml) was stirred for 2 h at RT. Filtration and evaporation of solvents gave the title compound (3.28 g). MS m/z (rel. intensity, 70 eV) 252 (M+, bp), 179 (94), 177 (40), 132 (55), 131 (63).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-1eeb636ac9a24272828b3c3b59ca6345 |
| Source note | uspto-grants-2013_09 |