Imidazole → HCID 58230556, compound

Participants

Reaction Steps

To a solution of (4-bromomethyl-2-methoxy-phenyl)-methanol (1.1 g, 4.76 mmol) in dichloromethane (15 mL) is added imidazole (0.861 g, 5.71 mmol) and tert-butylchlorodimethylsilane (0.971 g, 12.98 mmol) at 0° C. The reaction mixture is allowed to warm to room temperature and stirred for one hour. The reaction mixture is quenched with water and concentrated. The residue is diluted with DCM, washed with water (15 mL) and brine (15 mL), dried over sodium sulfate, filtered, and concentrated to give the title compound (1.1 g, 66.9%). 1H NMR (400 MHz, CDCl3) δ 7.43-7.41 (d, J=8 Hz, 1H), 7.00-6.98 (d, J=8 Hz, 1H), 6.94 (s, 1H), 4.73 (s, 2H), 4.50 (s, 2H), 3.83 (s, 3H), 0.95 (s, 9H), 0.10 (s, 6H).

Provenance & Evidence