反应详情

4-Methyl-pyrazole-1-carboxylic acid tert-butyl ester (0.875 g, 4.8 mmol), N-bromosuccinimide (0.897 g, 5.0 mmol), and benzoyl peroxide (0.058 g, 0.24 mmol) were combined in CCl4 (50 mL). The reaction was heated to reflux and stirred under a halogen lamp for 1 hour. The mixture was filtered and concentrated, and the residue was purified by silica gel chromatography to give the title compound, contaminated with a small amount of starting material.

1. temperatureThe reaction was heated
2. temperatureto reflux
3. filtrationThe mixture was filtered
4. concentrationconcentrated
5. customthe residue was purified by silica gel chromatography