Ethanol → Ethyl 2-Methyl-4-nitrobenzoate

HRID 390409Notes

Reaction equation

HRID 390409 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:19][CH2:20]O>>[CH2:19]([O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:2]=1[CH3:1])[CH3:20]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 747904-Nitro-o-toluic acid

Product 1

HCID 21345698Ethyl 2-Methyl-4-nitrobenzoate

Procedure

2-Methyl-4-nitrobenzoic acid (10 g, 55.2 mmol) in EtOH (200 mL) was treated with sulfuric acid (2 mL) and stirred at reflux until the reaction was complete. The mixture was worked-up and purified to give the title compound.

Workup

  1. temperatureat reflux until the reaction
  2. custompurified

Sources & evidence

ORD record
ord-e629ee00ce5b455a8a0ba08f90626792
Source dataset
uspto-grants-2013_02
Patent number
US08383654B2

Reaction notes

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