HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → Ethyl 2-(bromomethyl)-4-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 2-Methyl-4-nitrobenzoate | HCID 21345698 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 2-(bromomethyl)-4-nitrobenzoate | HCID 58066683 | — |
Reaction Steps
2-Methyl-4-nitro-benzoic acid ethyl ester (6.0 g, 28.7 mmol), N-bromosuccinimide (5.4 g, 30.3 mmol), and benzoyl peroxide (0.695 g, 2.87 mmol) were combined in CCl4 (250 mL). The reaction was heated to reflux and stirred under a halogen lamp overnight. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383654B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-f7a31bdb66ee4db6859c9b4543a86016 |
| Source note | uspto-grants-2013_02 |