Phosphorus tribromide → HCID 58066671, compound

Participants

Reaction Conditions

Reaction Steps

To N-(3-tert-butylsulfanylmethyl-4-hydroxymethyl-phenyl)-2,2-dimethyl-propionamide (1.6 g, 5.17 mmol) in DME (60 mL) at 0° C. was added phosphorus tribromide (0.54 mL, 5.69 mmol) slowly via syringe. The reaction was stirred at 0° C. for 20 minutes, until no starting material was seen by analytical tlc. The mixture was quenched with H2O and diluted with EtOAc (300 mL) and H2O (100 mL). The organic layer was separated and washed with H2O, and then dried, filtered, and concentrated to give the title compound.

Provenance & Evidence