HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(4-Fluorophenyl)-3-(pyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-4-fluorobenzene | HCID 522627 | — |
| Reactant | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| Product | 5-(4-Fluorophenyl)-3-(pyridin-3-yl)isoxazole | HCID 44546162 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-4-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.40-7.52 (m, 2H), 7.70-7.81 (m, 2H), 7.92-8.08 (m, 2H), 8.44 (dt, J=8.0, 1.9 Hz, 1H), 8.80 (d, J=4.4 Hz, 1H), 9.18 (s, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-94d051ac40e74450995f8cc53bfa44d0 |
| Source note | uspto-grants-2013_02 |