Ammonia → 3-(Pyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)isoxazole

Participants

Reaction Steps

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3-(trifluoromethyl)benzene (Aldrich, 85 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.64-7.76 (m, 1H), 7.81-7.96 (m, 2H), 7.98 (s, 1H), 8.20-8.30 (m, 2H), 8.41 (dt, J=8.1, 1.9 Hz, 1H), 8.79 (dd, J=4.8, 1.6 Hz, 1H), 9.17 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+.

Provenance & Evidence