HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(2,4-Difluorophenyl)-3-(pyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-2,4-difluorobenzene | HCID 5063820 | — |
| Reactant | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| Product | 5-(2,4-Difluorophenyl)-3-(pyridin-3-yl)isoxazole | HCID 44546227 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-2,4-difluorobenzene (Aldrich, 69 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.29-7.43 (m, 1H), 7.53-7.65 (m, 2H), 7.69 (dd, J=7.5, 4.7 Hz, 1H), 8.08 (td, J=8.7, 6.3 Hz, 1H), 8.48 (dt, J=7.9, 2.0 Hz, 1H), 8.78 (dd, J=4.9, 1.5 Hz, 1H), 9.23 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 259 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-06b91505ed964a7eb6601e5bb2bb727e |
| Source note | uspto-grants-2013_02 |