Ammonia → HCID 44546228, compound

HRID 390447Notes

Reaction equation

HRID 390447 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[F:19])#[CH:12].N>>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:11]1[O:1][N:2]=[C:3]([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:12]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6433581-Ethynyl-2-fluorobenzeneHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

Product 1

HCID 44546228HCID 44546228, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-2-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.34-7.56 (m, 2H), 7.58-7.74 (m, 3H), 8.02 (td, J=7.6, 1.7 Hz, 1H), 8.47 (dt, J=7.9, 2.0 Hz, 1H), 8.77 (dd, J=4.9, 1.5 Hz, 1H), 9.23 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.

Sources & evidence

ORD record
ord-911f9c8803ba4087b5c7430bdb3a2175
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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