Ammonia → 5-(3,4-Difluorophenyl)-3-(pyridin-3-yl)isoxazole

Participants

Reaction Steps

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 4-ethynyl-1,2-difluorobenzene (Apollo, 69 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.60-7.75 (m, 2H), 7.76-7.85 (m, 2H), 8.05 (ddd, J=11.4, 7.6, 2.4 Hz, 1H), 8.37 (dt, J=7.9, 2.0 Hz, 1H), 8.78 (dd, J=5.1, 1.7 Hz, 1H), 9.14 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 259 (M+H)+.

Provenance & Evidence