HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(2-Chlorophenyl)-3-(pyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Chloro-2-ethynylbenzene | HCID 585995 | — |
| Reactant | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| Product | 5-(2-Chlorophenyl)-3-(pyridin-3-yl)isoxazole | HCID 44546284 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-chloro-2-ethynylbenzene (Apollo, 68 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.43-7.56 (m, 3H), 7.56-7.70 (m, 2H), 7.98 (dd, J=5.9, 3.6 Hz, 1H), 8.39 (dt, J=7.9, 2.0 Hz, 1H), 8.67 (dd, J=4.8, 1.6 Hz, 1H), 9.12 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 259 (M+H)+, 257 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-3767e57ce0f84e73ba8aca14ad3974c2 |
| Source note | uspto-grants-2013_02 |