Ammonia → HCID 44546285, compound

HRID 390456Notes

Reaction equation

HRID 390456 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16])#[CH:12].N>>[NH2:16][C:15]1[CH:14]=[C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:12]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 104682Benzenamine, 3-ethynyl-HCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

Product 1

HCID 44546285HCID 44546285, compound

Procedure

The titled compound was prepared according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 3-ethynylaniline (Aldrich, 59 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 6.83 (dt, J=7.5, 1.9 Hz, 1H), 7.10-7.33 (m, 4H), 7.59 (dd, J=8.0, 4.9 Hz, 1H), 8.35 (dt, J=8.1, 1.9 Hz, 1H), 8.65 (dd, J=4.9, 1.5 Hz, 1H), 9.08 (d, J=1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 238 (M+H)+.

Sources & evidence

ORD record
ord-2ce3e6c2782146549dd8498986f96274
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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