HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(3-(3-(Pyridin-3-yl)isoxazol-5-yl)phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-(3-Ethynylphenyl)ethanone | HCID 15181428 | — |
| Reactant | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| Product | 1-(3-(3-(Pyridin-3-yl)isoxazol-5-yl)phenyl)ethanone | HCID 44546286 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-(3-ethynylphenyl)ethanone (GFS Chemicals, 72 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 2.70 (s, 3H), 7.67-7.85 (m, 2H), 7.94 (s, 1H), 8.13 (dt, J=5.1, 1.5 Hz, 1H), 8.18 (dt, J=7.6, 1.5 Hz, 1H), 8.40-8.54 (m, 2H), 8.80 (dd, J=5.2, 1.6 Hz, 1H), 9.20 (d, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 265 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-00dfbb9472354d1584080d7c50931ffa |
| Source note | uspto-grants-2013_02 |