HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Ethynylbenzonitrile | HCID 12088964 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44546287 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.55 (s, 1H), 7.75 (t, J=7.9 Hz, 1H), 7.88 (dt, J=7.9, 1.4 Hz, 1H), 8.18 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.23 (ddd, J=7.9, 2.0, 1.2 Hz, 1H), 8.31 (t, J=1.6 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.98 (t, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-44d5ca19e8cc4beea375f60dd735de39 |
| Source note | uspto-grants-2013_02 |