HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3-Fluorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-3-fluorobenzene | HCID 520218 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 5-(3-Fluorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole | HCID 44546288 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1-ethynyl-3-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.20-7.35 (m, 1H), 7.46 (s, 1 H), 7.58 (td, J=8.0, 5.8 Hz, 1H), 7.68 (ddd, J=9.7, 2.5, 1.7 Hz, 1H), 7.76 (dt, J=8.0, 1.1 Hz, 1H), 8.17 (ddd, J=9.4, 2.8, 1.7 Hz, 1H), 8.61 (d, J=2.7 Hz, 1H), 8.97 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 259 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-d5946c486d1649e8b0ff592732a4e0c1 |
| Source note | uspto-grants-2013_02 |