HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-Fluoropyridin-3-yl)-5-(3,4,5-trifluorophenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Ethynyl-1,2,3-trifluorobenzene | HCID 22709071 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 3-(5-Fluoropyridin-3-yl)-5-(3,4,5-trifluorophenyl)isoxazole | HCID 44546350 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 5-ethynyl-1,2,3-trifluorobenzene (Apollo, 78 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.49 (s, 1H), 7.76 (dd, J=8.3, 6.6 Hz, 2H), 0.16 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.62 (d, J=2.7 Hz, 1H), 8.95 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 295 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ef3d8408acee41db98657f89e33415f0 |
| Source note | uspto-grants-2013_02 |