HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(4-Fluoro-3-methylphenyl)-3-(5-fluoropyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Ethynyl-1-fluoro-2-methylbenzene | HCID 16213797 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 5-(4-Fluoro-3-methylphenyl)-3-(5-fluoropyridin-3-yl)isoxazole | HCID 44546352 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 4-ethynyl-1-fluoro-2-methylbenzene (Aldrich, 67 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 2.37 (d, J=2.0 Hz, 3H), 7.21 (t, J=8.9 Hz, 1H), 7.33 (s, 1H), 7.73-7.80 (m, 1H), 7.83 (dd, J=6.6, 1.9 Hz, 1H), 8.16 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.60 (d, J=2.7 Hz, 1H), 8.96 (t, J=1.5 Hz, 1 H) ppm; MS (DCI/NH3) m/z 273 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-806fa3256c8743e797ff71179939f8b8 |
| Source note | uspto-grants-2013_02 |