HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(5-fluoropyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Ethynyl-2-fluoro-1-(trifluoromethoxy)benzene | HCID 16218253 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 5-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(5-fluoropyridin-3-yl)isoxazole | HCID 44546413 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 4-ethynyl-2-fluoro-1-(trifluoromethoxy)benzene (Apollo, 102 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.51 (s, 1H), 7.59-7.69 (m, 1H), 7.85 (ddd, J=8.8, 2.0, 1.4 Hz, 1H), 7.93 (dd, J=10.9, 2.0 Hz, 1H), 8.17 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.62 (d, J=2.7 Hz, 1H), 8.97 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 343 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-5d57500cd69c438f964bf5d338aa0226 |
| Source note | uspto-grants-2013_02 |