HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(2-Chlorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Chloro-2-ethynylbenzene | HCID 585995 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 5-(2-Chlorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole | HCID 44546416 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1-chloro-2-ethynylbenzene (Apollo, 68 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.48-7.54 (m, 2H), 7.56 (s, 1H), 7.59-7.68 (m, 1H), 7.97 (dd, J=5.9, 3.9 Hz, 1H), 8.21 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.61 (d, J=2.7 Hz, 1H), 9.00 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 277 (M+H)+, 275 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6d08dc476c86468c87e75ac2aec472f7 |
| Source note | uspto-grants-2013_02 |