Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-(Pyridin-3-yl)-3-(pyrimidin-5-yl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 3-Ethynylpyridine | HCID 186003 | — |
| 반응물 | N-Hydroxypyrimidine-5-carbimidoyl chloride | HCID 86636847 | — |
| 생성물 | 5-(Pyridin-3-yl)-3-(pyrimidin-5-yl)isoxazole | HCID 69000103 | — |
반응 단계
The titled compound was prepared as the bishydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 3-ethynylpyridine (Aldrich, 52 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.70 (ddd, J=8.1, 4.9, 0.8 Hz, 1H), 7.96 (s, 1H), 8.37 (ddd, J=8.2, 1.9, 1.7 Hz, 1H), 8.77 (dd, J=4.7, 1.7 Hz, 1H), 9.17 (dd, J=2.2, 0.8 Hz, 1H), 9.34 (s, 2H), 9.36 (s, 1H) ppm; MS (DCI/NH3) m/z 225 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-82b3bb5ac76e4662a26d831cfae6d628 |
| 출처 메모 | uspto-grants-2013_02 |