HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(2,4-Difluorophenyl)-3-(pyrimidin-5-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-2,4-difluorobenzene | HCID 5063820 | — |
| Reactant | N-Hydroxypyrimidine-5-carbimidoyl chloride | HCID 86636847 | — |
| Product | 5-(2,4-Difluorophenyl)-3-(pyrimidin-5-yl)isoxazole | HCID 44546417 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-ethynyl-2,4-difluorobenzene (Aldrich, 69 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.30-7.42 (m, 1H), 7.61 (ddd, J=11.5, 9.1, 2.4 Hz, 1H), 7.68 (d, J=3.2 Hz, 1H), 8.08 (td, J=8.6, 6.5 Hz, 1H), 9.35 (s, 1H), 9.39 (s, 2H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-cccfc56def214896b2f2adf4e6d68a3f |
| Source note | uspto-grants-2013_02 |