HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-(3-(Pyrimidin-5-yl)isoxazol-5-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| Reactant | N-Hydroxypyrimidine-5-carbimidoyl chloride | HCID 86636847 | — |
| Product | 4-(3-(Pyrimidin-5-yl)isoxazol-5-yl)benzonitrile | HCID 44546419 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 4-ethynylbenzonitrile (Aldrich, 64 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ7.99 (s, 1H), 8.10 (s, 4H), 9.34 (s, 2H), 9.36 (s, 1H) ppm; MS (DCI/NH3) m/z 249 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-c47057bc60b743aea1edc8ce5122767d |
| Source note | uspto-grants-2013_02 |