Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-(3,5-Difluorophenyl)-3-(pyrimidin-5-yl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 1-Ethynyl-3,5-difluorobenzene | HCID 4206806 | — |
| 반응물 | N-Hydroxypyrimidine-5-carbimidoyl chloride | HCID 86636847 | — |
| 생성물 | 5-(3,5-Difluorophenyl)-3-(pyrimidin-5-yl)isoxazole | HCID 44546420 | — |
반응 단계
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-ethynyl-3,5-difluorobenzene (Apollo, 69 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.52 (tt, J=9.5, 2.4 Hz, 1H), 7.62-7.78 (m, 2H), 7.93 (s, 1H), 9.30 (s, 2H), 9.36 (s, 1H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-848522a5605549cd8986f7bb3edcfadb |
| 출처 메모 | uspto-grants-2013_02 |