HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3-Fluorophenyl)-3-(pyrimidin-5-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-3-fluorobenzene | HCID 520218 | — |
| Reactant | N-Hydroxypyrimidine-5-carbimidoyl chloride | HCID 86636847 | — |
| Product | 5-(3-Fluorophenyl)-3-(pyrimidin-5-yl)isoxazole | HCID 44546421 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-ethynyl-3-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.35-7.51 (m, 1H), 7.67 (td, J=8.1, 5.9 Hz, 1H), 7.73-7.82 (m, 2H), 7.86 (s, 1H), 9.32 (s, 2H), 9.36 (s, 1H) ppm; MS (DCI/NH3) m/z 242 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-211908f9cd9e4f1881a914397bf39778 |
| Source note | uspto-grants-2013_02 |