Ammonia → HCID 44546480, compound

HRID 390484Notes

Reaction equation

HRID 390484 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:5]=[N:6][CH:7]=[N:8][CH:9]=1.[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)#[CH:12].N>>[C:13]1([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[N:8][CH:9]=3)[CH:12]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 10821PhenylacetyleneHCID 86636847N-Hydroxypyrimidine-5-carbimidoyl chloride

Product 1

HCID 44546480HCID 44546480, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-ethynyl-benzene (Aldrich, 52 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.47-7.70 (m, 3H), 7.78 (s, 1H), 7.87-7.98 (m, 2H), 9.34 (s, 2H), 9.35 (s, 1H) ppm; MS (DCI/NH3) m/z 224 (M+H)+.

Sources & evidence

ORD record
ord-5c4c85e6da9047b5a2fc7e3fd9ae053d
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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