HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3,4-Dichlorophenyl)-3-(pyrimidin-5-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,4-Dichlorophenylacetylene | HCID 44119622 | — |
| Reactant | N-Hydroxypyrimidine-5-carbimidoyl chloride | HCID 86636847 | — |
| Product | 5-(3,4-Dichlorophenyl)-3-(pyrimidin-5-yl)isoxazole | HCID 44546484 | — |
Reaction Steps
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1,2-dichloro-4-ethynylbenzene (Aldrich, 86 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.86-7.96 (m, 3H), 8.20 (d, J=1.7 Hz, 1H), 9.31 (s, 2H), 9.36 (s, 1H) ppm; MS (DCI/NH3) m/z 294 (M+H)+, 292 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-85fe5e8399a2475da350c97ad07ebcdc |
| Source note | uspto-grants-2013_02 |