Ammonia → HCID 44546485, compound

HRID 390489Notes

Reaction equation

HRID 390489 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:5]=[N:6][CH:7]=[N:8][CH:9]=1.[F:11][CH:12]([F:22])[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[CH:21])[CH:15]=1.N>>[F:11][CH:12]([F:22])[O:13][C:14]1[CH:15]=[C:16]([C:20]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[N:8][CH:9]=3)[CH:21]=2)[CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 27784953-(Difluoromethoxy)phenylacetyleneHCID 86636847N-Hydroxypyrimidine-5-carbimidoyl chloride

Product 1

HCID 44546485HCID 44546485, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-(difluoromethoxy)-3-ethynylbenzene (Fluorochemicals, 84 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.33-7.46 (m, 2H), 7.56-7.74 (m, 2H), 7.81 (dt, J=7.9, 1.1 Hz, 1H), 7.87 (s, 1H), 9.33 (s, 2H), 9.35 (s, 1H) ppm; MS (DCI/NH3) m/z 290 (M+H)+.

Sources & evidence

ORD record
ord-c1cfbc9ec0654c67aba007769d53ff01
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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