Ammonia → HCID 44546486, compound

HRID 390490Notes

Reaction equation

HRID 390490 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:5]=[N:6][CH:7]=[N:8][CH:9]=1.[C:11]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)#[CH:12].N>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[N:8][CH:9]=3)[CH:12]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 5226271-Ethynyl-4-fluorobenzeneHCID 86636847N-Hydroxypyrimidine-5-carbimidoyl chloride

Product 1

HCID 44546486HCID 44546486, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-ethynyl-4-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.40-7.57 (m, 2H), 7.76 (s, 1H), 7.90-8.06 (m, 2H), 9.32 (s, 2H), 9.35 (s, 1H) ppm; MS (DCI/NH3) m/z 242 (M+H)+.

Sources & evidence

ORD record
ord-3cc1762d919d4d2b94a02fa9a4ca0fa4
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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