HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-(3-Ethynylphenyl)ethanone | HCID 15181428 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 1-(3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)phenyl)ethanone | HCID 44546545 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of product of Example 28B (88 mg, 0.5 mmol) and 1-(3-ethynylphenyl)ethanone (GFS Chemicals, 72 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 2.69 (s, 3H), 7.54 (s, 1H), 7.71 (t, J=7.5 Hz, 1H), 8.08-8.24 (m, 3H), 8.51 (t, J=1.8 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.99 (t, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 283 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-df7af49952e241ac8e81e07b48ed8615 |
| Source note | uspto-grants-2013_02 |