HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3,5-Dimethoxyphenyl)-3-(5-fluoropyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-3,5-dimethoxybenzene | HCID 4661321 | — |
| Reactant | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Product | 5-(3,5-Dimethoxyphenyl)-3-(5-fluoropyridin-3-yl)isoxazole | HCID 44546544 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of product of Example 28B (88 mg, 0.5 mmol) and 1-ethynyl-3,5-dimethoxybenzene (Aldrich, 81 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) 83.87 (s, 6H), 6.64 (t, J=2.2 Hz, 1H), 7.06 (d, J=2.4 Hz, 2H), 7.40 (s, 1H), 8.16 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.60 (d, J=2.7 Hz, 1H), 8.96 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 301 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-27a9755067294451ac08a834d733d829 |
| Source note | uspto-grants-2013_02 |