HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Fluoro-5-(3-(pyridin-3-yl)isoxazol-5-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| Reactant | 5-Ethynyl-2-fluorobenzonitrile | HCID 53429295 | — |
| Product | 2-Fluoro-5-(3-(pyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44546547 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and the product of Example 68A (73 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.49 (s, 1H), 7.52-7.68 (m, 2H), 8.28 (ddd, J=8.8, 5.1, 2.4 Hz, 1H), 8.33-8.41 (m, 2H), 8.68 (dd, J=4.9, 1.5 Hz, 1H), 9.09 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-8dddfa36a97348dfb12af912ab9649d1 |
| Source note | uspto-grants-2013_02 |