HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-Chloropyridin-3-yl)-5-(pyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Ethynylpyridine | HCID 186003 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 3-(5-Chloropyridin-3-yl)-5-(pyridin-3-yl)isoxazole | HCID 69000387 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 3-ethynylpyridine (Aldrich, 31.0 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.65 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 7.92 (s, 1H), 8.30 (dt, J=7.7, 2.2, 2.0 Hz, 1H), 8.45 (t, J=2.2 Hz, 1H), 8.75 (dd, J=4.8, 1.6 Hz, 1H), 8.82 (d, J=2.4 Hz, 1H), 9.09 (d, J=2.0 Hz, 1H), 9.13 (dd, J=2.4, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 260 (M+H)+, 258 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-65832cb06e2c4c7798f6f6cce5113150 |
| Source note | uspto-grants-2013_02 |