HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-Chloropyridin-3-yl)-5-(2,4-difluorophenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Ethynyl-2,4-difluorobenzene | HCID 5063820 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 3-(5-Chloropyridin-3-yl)-5-(2,4-difluorophenyl)isoxazole | HCID 44545538 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 1-ethynyl-2,4-difluorobenzene (Aldrich, 41 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.30-7.43 (m, 1H), 7.61 (ddd, J=11.4, 9.2, 2.8 Hz, 1H), 7.68 (d, J=3.2 Hz, 1H), 8.07 (td, J=8.5, 6.3 Hz, 1H), 8.54 (t, J=2.0 Hz, 1H), 8.80 (d, J=2.4 Hz, 1H), 9.15 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 293 (M+H)+, 295 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-33344dc0e1ad4d50b572892fce528340 |
| Source note | uspto-grants-2013_02 |