HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-(3-(5-Chloropyridin-3-yl)isoxazol-5-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 4-(3-(5-Chloropyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44545540 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 4-ethynylbenzonitrile (Aldrich, 38 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ8.00 (s, 1H), 8.09 (s, 4H), 8.45 (t, J=2.1 Hz, 1H), 8.82 (d, J=2.4 Hz, 1H), 9.09 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 282 (M+H)+, 284 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-7a490b8dbe6c4b858a4bc6c134ccf792 |
| Source note | uspto-grants-2013_02 |