HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → 3-(5-Chloropyridin-3-yl)-5-(3,4,5-trifluorophenyl)isoxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 5-Ethynyl-1,2,3-trifluorobenzene | HCID 22709071 | — |
| Edukt | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Produkt | 3-(5-Chloropyridin-3-yl)-5-(3,4,5-trifluorophenyl)isoxazole | HCID 44545542 | — |
Reaktionsschritte
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 5-ethynyl-1,2,3-trifluorobenzene (Apollo, 47 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.87 (s, 1H), 7.92 (dd, J=8.6, 6.6 Hz, 2H), 8.39 (t, J=2.0 Hz, 1H), 8.82 (d, J=2.4 Hz, 1H), 9.04 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 311 (M+H)+, 313 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08383658B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-3bd966ff9e4645d39d55a0f88cf4e6fa |
| Quellennotiz | uspto-grants-2013_02 |