HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-Chloropyridin-3-yl)-5-p-tolylisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | p-Ethynyltoluene | HCID 13018 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 3-(5-Chloropyridin-3-yl)-5-p-tolylisoxazole | HCID 44545543 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 1-ethynyl-4-methylbenzene (Apollo, 35 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 2.40 (s, 3H), 7.41 (d, J=8.1 Hz, 2 H), 7.71 (s, 1H), 7.80 (d, J=8.1 Hz, 2H), 8.43 (dd, J=2.4, 1.7 Hz, 1H), 8.80 (d, J=2.4 Hz, 1H), 9.08 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 271 (M+H)+, 273 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-3198d18c775244bca55265ea55dba054 |
| Source note | uspto-grants-2013_02 |