HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-Chloropyridin-3-yl)-5-(3,4-difluorophenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,4-Difluorophenylacetylene | HCID 13878454 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 3-(5-Chloropyridin-3-yl)-5-(3,4-difluorophenyl)isoxazole | HCID 44545544 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 4-ethynyl-1,2-difluorobenzene (Apollo, 41 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.63-7.81 (m, 2H), 7.82 (s, 1H), 8.02 (ddd, J=11.4, 7.6, 2.0 Hz, 1H), 8.41 (t, J=2.0 Hz, 1H), 8.81 (d, J=2.4 Hz, 1H), 9.06 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+, 293 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-7b3261f6343e4177843d083ecddaf8ca |
| Source note | uspto-grants-2013_02 |